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2024 Vol.36, Issue 1

Research Article

Attenuation of Experimental Autoimmune Neuritis in Lewis Rats by Resveratrol

길랑-바레 증후군 동물모델에서 Resveratrol의 효능에 대한 연구

Seukchan Kim1
,
Jeungho Moon2
,
Meejung Ahn3*
김 석찬1
,
문 정호2
,
안 미정3*
1M.S. Student, Department of Animal Science of Graduate School, Sangji University, Wonju 26339, Korea
2Undergraduate Student, Department of Animal Science, Sangji University, Wonju 26339, Korea
3Professor, Department of Animal Science, Sangji University, Wonju 26339, Korea
1상지대학교 일반대학원 동물생명자원학과 석사과정
2상지대학교 동물자원학과 학부학생
3상지대학교 동물자원학과 교수
*Corresponding Author
31 March 2024. pp. 1-11
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Abstract

The study evaluated the therapeutic effects of resveratrol on experimental autoimmune neuritis (EAN), widely used in the experimental studies of human peripheral demyelinating diseases, including Guillain-Barré syndrome (GBS). EAN was induced in Lewis rats by immunization with a neurogenic peptide homologous to amino acids 53–78 of bovine myelin P2 protein. The rats were monitored daily for clinical symptoms such as paralysis, and the levels of inflammatory mediators were analyzed using immunohistochemistry. The daily oral administration of resveratrol to the EAN-treated rats was observed to significantly reduce the severity of paralysis (p < 0.05). Histopathological examinations additionally confirmed that resveratrol mitigated the inflammation in the sciatic nerves after EAN induction suppressed the infiltration of ionized calcium-binding adaptor molecule-1 positive inflammatory cells, and reduced the number of iNOS-positive inflammatory cells compared to the vehicle-treated group (p < 0.05). Furthermore, the resveratrol-treated group exhibited a decrease in the production of pro-inflammatory cytokines, including tumor necrosis factor (TNF)-α(p < 0.05). When considered together, these results suggest that resveratrol alleviates neuroinflammation in the sciatic nerves of EAN-induced rats by systemically suppressing circulating pro-inflammatory factors.

Keywords
Experimental Autoimmune Neuritis
iNOS
Resveratrol
Sciatic nerves
TNF-α
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Information
  • Publisher :Agriculture and Life Sciences Research Institute, Kangwon National University
  • Publisher(Ko) :강원대학교 농업생명과학대학 농업생명과학연구원
  • Journal Title :Journal of Agricultural, Life and Environmental Sciences
  • Journal Title(Ko) :농업생명환경연구
  • Volume : 36
  • No :1
  • Pages :1-11
  • Received Date : 2024-01-11
  • Revised Date : 2024-01-15
  • Accepted Date : 2024-01-15
  • DOI :https://doi.org/10.22698/jales.20240001
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